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KMID : 0377619740260040465
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Korean Jungang Medical Journal
1974 Volume.26 No. 4 p.465 ~ p.470
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The Effect of Vitamin C on the Metabolism of Vitamin A in the Rats
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Abstract
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In order to know effect of vitamin C on the metabolism of vitamin A, the following experiments were performed.
Experiment 1
10,000 1.U.-of vitamin A was administered per day by the tube feeding ° method for two weeks to male albino rats (110-130 gm of body weight). Then the rats were divided into two groups. The first group (control) was injected with 0.9% NaCI solution and the second group (vitamin C injected group) was injected with 10 mg -of vitamin C and the vitamin A transfer from the liver to the blood was observed.
Experiment 2
10, 000 I. U. of vitamin A was administered by the tube feeding method for one week, then the rats fasted 24 hours and 10mg of vitamin C was injected and the vitamin A transfer from the liver to the blood was observed at 1, 2 and 5 hour intervals. Experiment 3
10,000 I. U. of vitamin A was administered by the tube feeding method, at the same time 10 mg of vitamin C was injected. Vitamin A in the blood was determined at 1., 2 and 5 hour intervals.
The following results were obtained
The injection of vitamin C enhanced the transfer of vitamin A from the liver to the blood of the rats. The injection of vitamin C did not effect the absorption of vitamin A in the intestine of rats.
It is concluded that vitamin C may stimulate the liver cells. and enhance the transfer of vitamin A from the blood to the liver in. cases of high concentration of vitamin A in the blood and from the liver to the blood in cases of high accumulation of vitamin A in the liver.
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